Zulresso

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Zulresso is the first medication specifically approved to treat post-partum depression in new mothers. Zulresso is administered in a healthcare facility over 2.5 days.

Zulresso Overview

Reviewed: March 25, 2019
Updated: 

Zulresso is a prescription medication used to treat post-partum depression. Zulresso belongs to a group of drugs called steroid hormone derivatives, which help regulate chemicals in the brain known to play a role in mood.  

This medication is available in an injectable form to be given into intravenously (IV) by a healthcare professional.

Common side effects of Zulresso include sedation/sleepiness, dry mouth, loss of consciousness and flushing/hot flashes.

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Zulresso Drug Class

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Zulresso is part of the drug class:

Zulresso FDA Warning

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WARNING: EXCESSIVE SEDATION AND SUDDEN LOSS OF CONSCIOUSNESS

Patients treated with ZULRESSO are at risk of excessive sedation or sudden loss of consciousness during administration.

Because of the risk of serious harm, patients must be monitored for excessive sedation and sudden loss of consciousness and have continuous pulse oximetry monitoring. Patients must be accompanied during interactions with their child(ren).

Because of these risks, ZULRESSO is available only through a restricted program under a Risk Evaluation and Mitigation Strategy (REMS) called the ZULRESSO REMS.