Synjardy XR

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Synjardy XR is used to treat type 2 diabetes. It should be combined with a healthy diet and exercise to control blood sugar levels.

Synjardy XR Overview

Reviewed: March 7, 2017
Updated: 

Synjardy XR is a prescription medication used to treat type 2 diabetes. It is a single product containing 2 medications: empagliflozin and metformin.

Empagliflozin belongs to a group of drugs called sodium-glucose cotransporter 2 (SGLT2) inhibitors. These drugs work by stopping the reabsorption of glucose by the kidney, increasing glucose excretion from the body, and lowering blood sugar levels. Metformin belongs to a group of drugs called biguanides. These drugs work by helping your body respond better to the insulin it makes naturally, decreasing the amount of sugar your liver makes and decreasing the amount of sugar your intestines absorb.

This medication comes in tablet form and is taken once daily with a meal in the morning.

Swallow the tablet whole; do not split, crush, dissolve, or chew.

Common side effects include diarrhea, nausea/vomiting, gas, stomach discomfort, indigestion, weakness, and headache. Synjardy XR may also cause urinary tract infections and female genital yeast infections.

Synjardy XR can also cause low blood sugar, which can cause drowsiness and dizziness. Do not drive or operate heavy machinery until you know how Synjardy XR affects you.

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Synjardy XR Drug Class

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Synjardy XR is part of the drug class:

Synjardy XR FDA Warning

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WARNING: LACTIC ACIDOSIS

  • Lactic acidosis is a rare, but serious, complication that can occur due to metformin accumulation. The risk increases with conditions such as renal impairment, sepsis, dehydration, excess alcohol intake, hepatic impairment, and acute congestive heart failure.
  • The onset is often subtle, accompanied only by nonspecific symptoms such as malaise, myalgias, respiratory distress, increasing somnolence, and nonspecific abdominal distress.
  • Laboratory abnormalities include low pH, increased anion gap, and elevated blood lactate.
  • If acidosis is suspected, Synjardy XR should be discontinued and the patient should be hospitalized immediately.