Ontruzant

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Ontruzant is used to treat certain breast and stomach cancers. Ontruzant can cause heart and lung problems and is not safe for pregnant or breastfeeding mothers.

Ontruzant Overview

Reviewed: February 20, 2019
Updated: 

Ontruzant is a prescription medication used to treat certain types of breast or digestive tract cancers in adults. Herzuma belongs to a group of drugs called HER2/neu receptor antagonists. These work binding to human epithelial growth factor receptor (HER2) and prevents the survival of cancer tumors dependent on HER2.

This medication is available in an injectable form to be given directly into a vein (IV) by a healthcare professional.

Common side effects of Ontruzant include headache, diarrhea, nausea, fever, chills, infectin, rash, weight loss, or changes in blood cell counts.

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Ontruzant Drug Class

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Ontruzant is part of the drug class:

Ontruzant FDA Warning

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Cardiomyopathy: trastuzumab products can result in subclinical and clinical cardiac failure manifesting as CHF, and decreased LVEF, with greatest risk when administered concurrently with anthracyclines. Evaluate cardiac function prior to and during treatment. Discontinue Ontruzant for cardiomyopathy. 

Infusion Reactions, Pulmonary Toxicity: Discontinue Ontruzant for anaphylaxis, angioedema, interstitial pneumonitis, or acute respiratory distress syndrome.

Embryo-Fetal Toxicity: Exposure to trastuzumab products during pregnancy can result in oligohydramnios, in some cases complicated by pulmonary hypoplasia and neonatal death. Advise patients of these risks and the need for effective contraception.