Camzyos

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Camzyos is used to treat adults with symptomatic obstructive hypertrophic cardiomyopathy (HCM).

Camzyos Overview

Reviewed: November 22, 2022
Updated: 

Camzyos is a prescription medication used to treat adults with symptomatic obstructive hypertrophic cardiomyopathy (HCM).

Camzyos belongs to a group of drugs called cardiac myosin inhibitors. With HCM, the heart muscle contracts too much. Camzyos works by binding to a heart protein called myosin to allow the heart muscle to relax more.

This medication comes in capsule form. It is taken once daily. Swallow Camzyos capsules whole. Do not crush, chew or open the capsules.

Common side effects include dizziness and fainting. Do not operate heavy machinery until you know how this medication affects you.

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Camzyos FDA Warning

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WARNING: RISK OF HEART FAILURE

Camzyos reduces left ventricular ejection fraction (LVEF) and can cause heart failure due to systolic dysfunction.

Echocardiogram assessments of LVEF are required prior to and during treatment with Camzyos. Initiation of Camzyos in patients with LVEF <55% is not recommended. Interrupt Camzyos if LVEF is <50% at any visit or if the patient experiences heart failure symptoms or worsening clinical status.

Concomitant use of Camzyos with certain cytochrome P450 inhibitors or discontinuation of certain cytochrome P450 inducers may increase the risk of heart failure due to systolic dysfunction; therefore, the use of Camzyos is contraindicated with the following:

•Moderate to strong CYP2C19 inhibitors or strong CYP3A4 inhibitors
•Moderate to strong CYP2C19 inducers or moderate to strong CYP3A4 inducers

Because of the risk of heart failure due to systolic dysfunction, Camzyos is available only through a restricted program under a Risk Evaluation and Mitigation Strategy (REMS) called Camzyos REMS PROGRAM.