Arymo ER

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Arymo ER is a strong opioid pain medication used to manage pain severe enough to require daily, around-the-clock, long-term treatment with an opioid. Never give anyone else this medication.

Arymo ER Overview

Reviewed: March 29, 2017
Updated: 

Arymo ER is a prescription medication used to relieve severe pain in adults who require around-the-clock, long-term treatment.

Arymo ER belongs to a group of drugs called opioid analgesics. These drugs work by changing the way the brain and nervous system respond to pain.

This medication comes in extended-release tablet form and is typically taken two to three times daily with a full glass of water. Do not chew, divide, or break Arymo ER tablets. Swallow Arymo ER tablets whole.

Common side effects include constipation, nausea, and abdominal pain. Arymo ER can make you dizzy or sleepy. Do not drive or operate heavy machinery until you know how it affects you.

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  • Other
  • Dyspnea
  • Pain, Intractable

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Arymo ER FDA Warning

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WARNING: ADDICTION, ABUSE, AND MISUSE; LIFE-THREATENING RESPIRATORY DEPRESSION; ACCIDENTAL INGESTION; NEONATAL OPIOID WITHDRAWAL SYNDROME; AND RISKS FROM CONCOMITANT USE WITH BENZODIAZEPINES OR OTHER CNS DEPRESSANTS

  • Addiction, Abuse, and Misuse
    • ARYMO™ ER exposes patients and other users to the risks of opioid addiction, abuse, and misuse, which can lead to overdose and death. 
  • Life-Threatening Respiratory Depression
    • Serious, life-threatening, or fatal respiratory depression may occur with use of ARYMO ER. Swallow ARYMO ER tablets whole; crushing, chewing, or dissolving ARYMO ER tablets can cause rapid release and absorption of a potentially fatal dose of morphine. 
  • Accidental Ingestion
    • Accidental ingestion of even one dose of ARYMO ER, especially by children, can result in a fatal overdose of morphine.
  • Neonatal Opioid Withdrawal Syndrome
    • Prolonged use of ARYMO ER during pregnancy can result in neonatal opioid withdrawal syndrome, which may be life-threatening if not recognized and treated, and requires management according to protocols developed by neonatology experts. 
  • Risks From Concomitant Use With Benzodiazepines Or Other CNS Depressants
    • Concomitant use of opioids with benzodiazepines or other central nervous system (CNS) depressants, including alcohol, may result in profound sedation, respiratory depression, coma, and death.