Andexxa

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Andexxa is used to reverse life-threatening or uncontrolled bleeding in patients on rivaroxaban and apixaban. Resume anticoagulant therapy as soon as medically appropriate.

Andexxa Overview

Reviewed: June 20, 2018
Updated: 

Andexxa is a prescription medication used in patients treated with rivaroxaban and apixaban, when reversal of anticoagulation is needed due to life-threatening or uncontrolled bleeding.

Andexxa belongs to a group of drugs called Factor Xa Inhibitor Antidotes. It acts as a decoy, binding to factor Xa inhibitors and neutralizing their anticoagulant effect.

This medication comes in an injectable form to be given directly into the vein by a healthcare provider. 

Common side effects of Andexxa include urinary tract infections, pneumonia, and infusion-related reactions.

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Andexxa Drug Class

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Andexxa is part of the drug class:

Andexxa FDA Warning

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WARNING: THROMBOEMBOLIC RISKS, ISCHEMIC RISKS, CARDIAC ARREST, AND SUDDEN DEATHS

Treatment with Andexxa has been associated with serious and life-threatening adverse events, including:

  • Arterial and venous thromboembolic events
  • Ischemic events, including myocardial infarction and ischemic stroke
  • Cardiac arrest
  • Sudden deaths

Monitor for thromboembolic events and initiate anticoagulation when medically appropriate. Monitor for symptoms and signs that precede cardiac arrest and provide treatment as needed.